Santa Clara is a town in Franklin County, New York, in the Malone metro area. The population was 332 at the 2020 census. Population in the year 2010: 345.

Santa Clara, a town within the Adirondack Park. Southwest of the Village of Malone, is the second largest town in Franklin County. The south part of the town is dominated by numerous lakes. Including 58 ponds of the Saint Regis Canoe Area. Presently the only Canoe Wilderness Area in the park, as well as most of 4,700-acre (19 km2) Upper Saranac Lake.

Formed from part of the Town of Brandon in 1888. The Town of Santa Clara, the name, was derived from the wife of an early town businessman, John Hurd. An addition from Brandon was added to Santa Clara in 1896.

William Rockefeller began buying property in the town around 1896 in order of establish an estate, used by members of his family during the summer.

The latitude of Santa Clara is 44.463N. The longitude is -74.391W. It is in the Eastern Standard time zone. Elevation is 1,588 feet. Land Area is 175.02 Square miles.